diff --git a/lib/jasmine-core/jasmine.js b/lib/jasmine-core/jasmine.js
index 574ee05d..396c15a7 100644
--- a/lib/jasmine-core/jasmine.js
+++ b/lib/jasmine-core/jasmine.js
@@ -1393,6 +1393,49 @@ getJasmineRequireObj().Env = function(j$) {
       }
     };
 
+    const handleThrowUnlessFailure = function(passed, result) {
+      if (!passed) {
+        /**
+         * @interface
+         * @name ThrowUnlessFailure
+         * @extends Error
+         * @description Represents a failure of an expectation evaluated with
+         * {@link throwUnless}. Properties of this error are a subset of the
+         * properties of {@link Expectation} and have the same values.
+         * @property {String} matcherName - The name of the matcher that was executed for this expectation.
+         * @property {String} message - The failure message for the expectation.
+         * @property {Boolean} passed - Whether the expectation passed or failed.
+         * @property {Object} expected - If the expectation failed, what was the expected value.
+         * @property {Object} actual - If the expectation failed, what actual value was produced.
+         */
+        const error = new Error(result.message);
+        error.passed = result.passed;
+        error.message = result.message;
+        error.expected = result.expected;
+        error.actual = result.actual;
+        error.matcherName = result.matcherName;
+        throw error;
+      }
+    };
+
+    const throwUnlessFactory = function(actual, spec) {
+      return j$.Expectation.factory({
+        matchersUtil: runableResources.makeMatchersUtil(),
+        customMatchers: runableResources.customMatchers(),
+        actual: actual,
+        addExpectationResult: handleThrowUnlessFailure
+      });
+    };
+
+    const throwUnlessAsyncFactory = function(actual, spec) {
+      return j$.Expectation.asyncFactory({
+        matchersUtil: runableResources.makeMatchersUtil(),
+        customAsyncMatchers: runableResources.customAsyncMatchers(),
+        actual: actual,
+        addExpectationResult: handleThrowUnlessFailure
+      });
+    };
+
     // TODO: Unify recordLateError with recordLateExpectation? The extra
     // diagnostic info added by the latter is probably useful in most cases.
     function recordLateError(error) {
@@ -1919,6 +1962,16 @@ getJasmineRequireObj().Env = function(j$) {
       return runable.asyncExpectationFactory(actual, runable);
     };
 
+    this.throwUnless = function(actual) {
+      const runable = runner.currentRunable();
+      return throwUnlessFactory(actual, runable);
+    };
+
+    this.throwUnlessAsync = function(actual) {
+      const runable = runner.currentRunable();
+      return throwUnlessAsyncFactory(actual, runable);
+    };
+
     this.beforeEach = function(beforeEachFunction, timeout) {
       ensureIsNotNested('beforeEach');
       ensureNonParallelOrInHelperOrInDescribe('beforeEach');
@@ -8228,6 +8281,50 @@ getJasmineRequireObj().interface = function(jasmine, env) {
       return env.expectAsync(actual);
     },
 
+    /**
+     * Create an asynchronous expectation for a spec and throw an error if it fails.
+     *
+     * This is intended to allow Jasmine matchers to be used with tools like
+     * testing-library's `waitFor`, which expect matcher failures to throw
+     * exceptions and not trigger a spec failure if the exception is caught.
+     * It can also be used to integration-test custom matchers.
+     *
+     * If the resulting expectation fails, a {@link ThrowUnlessFailure} will be
+     * thrown. A failed expectation will not result in a spec failure unless the
+     * exception propagates back to Jasmine, either via the call stack or via
+     * the global unhandled exception/unhandled promise rejection events.
+     * @name throwUnlessAsync
+     * @param actual
+     * @global
+     * @param {Object} actual - Actual computed value to test expectations against.
+     * @return {matchers}
+     */
+    throwUnlessAsync: function(actual) {
+      return env.throwUnless(actual);
+    },
+
+    /**
+     * Create an expectation for a spec and throw an error if it fails.
+     *
+     * This is intended to allow Jasmine matchers to be used with tools like
+     * testing-library's `waitFor`, which expect matcher failures to throw
+     * exceptions and not trigger a spec failure if the exception is caught.
+     * It can also be used to integration-test custom matchers.
+     *
+     * If the resulting expectation fails, a {@link ThrowUnlessFailure} will be
+     * thrown. A failed expectation will not result in a spec failure unless the
+     * exception propagates back to Jasmine, either via the call stack or via
+     * the global unhandled exception/unhandled promise rejection events.
+     * @name throwUnless
+     * @param actual
+     * @global
+     * @param {Object} actual - Actual computed value to test expectations against.
+     * @return {matchers}
+     */
+    throwUnless: function(actual) {
+      return env.throwUnless(actual);
+    },
+
     /**
      * Mark a spec as pending, expectation results will be ignored.
      * @name pending
diff --git a/package.json b/package.json
index 553cd8d9..ca068540 100644
--- a/package.json
+++ b/package.json
@@ -97,7 +97,8 @@
       ],
       "space-before-blocks": "error",
       "no-eval": "error",
-      "no-var": "error"
+      "no-var": "error",
+      "no-debugger": "error"
     }
   },
   "browserslist": [
diff --git a/spec/core/integration/EnvSpec.js b/spec/core/integration/EnvSpec.js
index f7a90cf5..97943aec 100644
--- a/spec/core/integration/EnvSpec.js
+++ b/spec/core/integration/EnvSpec.js
@@ -4334,6 +4334,115 @@ describe('Env integration', function() {
     }
   });
 
+  describe('throwUnless', function() {
+    it('throws when the matcher fails', async function() {
+      let thrown;
+
+      env.it('a spec', function() {
+        try {
+          env.throwUnless(1).toEqual(2);
+        } catch (e) {
+          thrown = e;
+        }
+      });
+
+      await env.execute();
+      expect(thrown).toBeInstanceOf(Error);
+      expect(thrown.passed).toEqual(false);
+      expect(thrown.matcherName).toEqual('toEqual');
+      expect(thrown.message).toEqual('Expected 1 to equal 2.');
+      expect(thrown.actual).toEqual(1);
+      expect(thrown.expected).toEqual(2);
+    });
+
+    it('does not throw when the matcher passes', async function() {
+      let threw = false;
+
+      env.it('a spec', function() {
+        try {
+          env.throwUnless(1).toEqual(1);
+        } catch (e) {
+          threw = true;
+        }
+      });
+
+      await env.execute();
+      expect(threw).toBe(false);
+    });
+
+    it('does not cause a failure if the error does not propagate back to jasmine', async function() {
+      env.it('a spec', function() {
+        try {
+          env.throwUnless(1).toEqual(2);
+        } catch (e) {}
+      });
+
+      const reporter = jasmine.createSpyObj('reporter', ['specDone']);
+      env.addReporter(reporter);
+
+      await env.execute();
+      expect(reporter.specDone).toHaveBeenCalledWith(
+        jasmine.objectContaining({ status: 'passed' })
+      );
+    });
+  });
+
+  describe('throwUnlessAsync', function() {
+    it('throws when the matcher fails', async function() {
+      const promise = Promise.resolve('a');
+      let thrown;
+
+      env.it('a spec', async function() {
+        try {
+          await env.throwUnlessAsync(promise).toBeResolvedTo('b');
+        } catch (e) {
+          thrown = e;
+        }
+      });
+
+      await env.execute();
+      expect(thrown).toBeInstanceOf(Error);
+      expect(thrown.passed).toEqual(false);
+      expect(thrown.matcherName).toEqual('toBeResolvedTo');
+      expect(thrown.message).toEqual(
+        "Expected a promise to be resolved to 'b' but it was resolved to 'a'."
+      );
+      expect(thrown.actual).toBe(promise);
+      expect(thrown.expected).toEqual('b');
+    });
+
+    it('does not throw when the matcher passes', async function() {
+      let threw = false;
+
+      env.it('a spec', async function() {
+        try {
+          await env.throwUnlessAsync(Promise.resolve()).toBeResolved();
+        } catch (e) {
+          threw = true;
+        }
+      });
+
+      await env.execute();
+      expect(threw).toBe(false);
+    });
+
+    it('does not cause a failure if the error does not propagate back to jasmine', async function() {
+      env.it('a spec', async function() {
+        try {
+          await env.throwUnlessAsync(Promise.resolve()).toBeRejected();
+        } catch (e) {}
+      });
+
+      const reporter = jasmine.createSpyObj('reporter', ['specDone']);
+      env.addReporter(reporter);
+
+      await env.execute();
+      expect(reporter.specDone).toHaveBeenCalledWith(
+        jasmine.objectContaining({ status: 'passed' })
+      );
+    });
+  });
+
   function browserEventMethods() {
     return {
       listeners_: { error: [], unhandledrejection: [] },
diff --git a/src/core/Env.js b/src/core/Env.js
index cccb87fb..b922cb26 100644
--- a/src/core/Env.js
+++ b/src/core/Env.js
@@ -264,6 +264,49 @@ getJasmineRequireObj().Env = function(j$) {
       }
     };
 
+    const handleThrowUnlessFailure = function(passed, result) {
+      if (!passed) {
+        /**
+         * @interface
+         * @name ThrowUnlessFailure
+         * @extends Error
+         * @description Represents a failure of an expectation evaluated with
+         * {@link throwUnless}. Properties of this error are a subset of the
+         * properties of {@link Expectation} and have the same values.
+         * @property {String} matcherName - The name of the matcher that was executed for this expectation.
+         * @property {String} message - The failure message for the expectation.
+         * @property {Boolean} passed - Whether the expectation passed or failed.
+         * @property {Object} expected - If the expectation failed, what was the expected value.
+         * @property {Object} actual - If the expectation failed, what actual value was produced.
+         */
+        const error = new Error(result.message);
+        error.passed = result.passed;
+        error.message = result.message;
+        error.expected = result.expected;
+        error.actual = result.actual;
+        error.matcherName = result.matcherName;
+        throw error;
+      }
+    };
+
+    const throwUnlessFactory = function(actual, spec) {
+      return j$.Expectation.factory({
+        matchersUtil: runableResources.makeMatchersUtil(),
+        customMatchers: runableResources.customMatchers(),
+        actual: actual,
+        addExpectationResult: handleThrowUnlessFailure
+      });
+    };
+
+    const throwUnlessAsyncFactory = function(actual, spec) {
+      return j$.Expectation.asyncFactory({
+        matchersUtil: runableResources.makeMatchersUtil(),
+        customAsyncMatchers: runableResources.customAsyncMatchers(),
+        actual: actual,
+        addExpectationResult: handleThrowUnlessFailure
+      });
+    };
+
     // TODO: Unify recordLateError with recordLateExpectation? The extra
     // diagnostic info added by the latter is probably useful in most cases.
     function recordLateError(error) {
@@ -790,6 +833,16 @@ getJasmineRequireObj().Env = function(j$) {
       return runable.asyncExpectationFactory(actual, runable);
     };
 
+    this.throwUnless = function(actual) {
+      const runable = runner.currentRunable();
+      return throwUnlessFactory(actual, runable);
+    };
+
+    this.throwUnlessAsync = function(actual) {
+      const runable = runner.currentRunable();
+      return throwUnlessAsyncFactory(actual, runable);
+    };
+
     this.beforeEach = function(beforeEachFunction, timeout) {
       ensureIsNotNested('beforeEach');
       ensureNonParallelOrInHelperOrInDescribe('beforeEach');
diff --git a/src/core/requireInterface.js b/src/core/requireInterface.js
index 1c7d4d00..71baa4d2 100644
--- a/src/core/requireInterface.js
+++ b/src/core/requireInterface.js
@@ -225,6 +225,50 @@ getJasmineRequireObj().interface = function(jasmine, env) {
       return env.expectAsync(actual);
     },
 
+    /**
+     * Create an asynchronous expectation for a spec and throw an error if it fails.
+     *
+     * This is intended to allow Jasmine matchers to be used with tools like
+     * testing-library's `waitFor`, which expect matcher failures to throw
+     * exceptions and not trigger a spec failure if the exception is caught.
+     * It can also be used to integration-test custom matchers.
+     *
+     * If the resulting expectation fails, a {@link ThrowUnlessFailure} will be
+     * thrown. A failed expectation will not result in a spec failure unless the
+     * exception propagates back to Jasmine, either via the call stack or via
+     * the global unhandled exception/unhandled promise rejection events.
+     * @name throwUnlessAsync
+     * @param actual
+     * @global
+     * @param {Object} actual - Actual computed value to test expectations against.
+     * @return {matchers}
+     */
+    throwUnlessAsync: function(actual) {
+      return env.throwUnless(actual);
+    },
+
+    /**
+     * Create an expectation for a spec and throw an error if it fails.
+     *
+     * This is intended to allow Jasmine matchers to be used with tools like
+     * testing-library's `waitFor`, which expect matcher failures to throw
+     * exceptions and not trigger a spec failure if the exception is caught.
+     * It can also be used to integration-test custom matchers.
+     *
+     * If the resulting expectation fails, a {@link ThrowUnlessFailure} will be
+     * thrown. A failed expectation will not result in a spec failure unless the
+     * exception propagates back to Jasmine, either via the call stack or via
+     * the global unhandled exception/unhandled promise rejection events.
+     * @name throwUnless
+     * @param actual
+     * @global
+     * @param {Object} actual - Actual computed value to test expectations against.
+     * @return {matchers}
+     */
+    throwUnless: function(actual) {
+      return env.throwUnless(actual);
+    },
+
     /**
      * Mark a spec as pending, expectation results will be ignored.
      * @name pending